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Among these proteins, is the serum- and glucocorticoid-dependent kinase (Waldegger et al., 1997), which is now recognized for its role in promoting hepatic insulin resistance (Zhou et al., 2021)

Without glutathione, each cell would become so ravaged by free radicals that it would disintegrate

Of these two, itraconazole has most promise as a pharmaceutical invention targeting NPC1, since it is already included in several clinical trials as an anti-cancer drug due to its ability to inhibit hedgehog pathway as well as due to its various anticancer activities including its ability to target multidrug resistance via ABC transporters [120]